abstract：:In recent years, because of its low immunogenicity and immunosuppression, mesenchymal stem cells (MSCs) have become a potential cell therapy for Graft-versus-host disease (GVHD). However, many experiments now focus on the interference of MSCs on T-cell proliferation in vitro and the prevention of GVHD in vivo. However...

authors： Wang Y

更新日期：2021-12-01 00:00:00

abstract：:Oleanolic acid (OA) is a natural cosmeceutical compound with various skin beneficial activities including inhibitory effect on hyaluronidase but the anti-hyaluronidase activity and mechanisms of action of its synthetic analogues remain unclear. Herein, a series of OA derivatives were synthesised and evaluated for thei...

authors： He H,Li H,Akanji T,Niu S,Luo Z,Li D,Seeram NP,Wu P,Ma H

更新日期：2021-12-01 00:00:00

abstract：:This study aimed to validate the chronic obstructive pulmonary disease (COPD) Population Screener (COPD-PS) questionnaire as a screening tool in a cohort of Chinese subjects who underwent a health examination, and to summarise its overall performance through a meta-analysis. We enrolled 997 subjects aged ≥40 years who...

authors： Gu Y,Zhang Y,Wen Q,Ouyang Y,Shen Y,Yu H,Wan C,Zhu J,Wen F

更新日期：2021-12-01 00:00:00

abstract：:Zika virus (ZIKV) infection can cause severe neurological disorders, including Guillain-Barre syndrome and meningoencephalitis in adults and microcephaly in fetuses. Here, we reveal that laminin receptor 1 (LAMR1) is a novel host resistance factor against ZIKV infection. Mechanistically, we found that LAMR1 binds to Z...

authors： Hu D,Wang Y,Li A,Li Q,Wu C,Shereen MA,Huang S,Wu K,Zhu Y,Wang W,Wu J

更新日期：2021-12-01 00:00:00

abstract：:This study was conducted to explore the molecular mechanisms of berberine (Ber) via peroxisome proliferator-activated receptor gamma (PPARG) in promoting in vitro maturation (IVM) and lipid metabolism of porcine oocytes. Our results showed that expression changes in PPARG influenced IVM and the lipid droplet content o...

authors： Dai JG,Huang XM,Zhang C,Gao JM

更新日期：2021-12-01 00:00:00

abstract：:Gastric cancer is one of the most common malignant tumors. Long non-coding RNAs play crucial roles in gastric cancer progression. This study investigated the effect of LINC01320 on malignant behaviors of gastric cancer cells and explored its possible molecular mechanism. LINC01320 expression in gastric cancer tissues ...

authors： Hu N,Ji H

更新日期：2021-12-01 00:00:00

abstract：:The current level of knowledge on transcriptome responses triggered by endotoxins and glucocorticoids in immune cells in pigs is limited. Therefore, in the present study, we treated porcine peripheral blood mononuclear cells (PBMCs) with lipopolysaccharide (LPS) and dexamethasone (DEX) separately or combined for 2 hou...

authors： Li Z,Trakooljul N,Hadlich F,Ponsuksili S,Wimmers K,Murani E

更新日期：2021-12-01 00:00:00

abstract：:The study aims to describe anthropometric data of Greenlandic preschool children, blood pressure (BP) measures and effects of maternal smoking during pregnancy in a follow-up of the ACCEPT birth cohort. The study included 102 children (55 boys and 47 girls) aged 3.5-5.5 years. Anthropometric measures included weight, ...

authors： Kok Grouleff M,Wielsøe M,Berthelsen D,Mulvad G,Isidor S,Long M,Bonefeld-Jørgensen EC

更新日期：2021-12-01 00:00:00

abstract：:Hepatic ischemia-reperfusion injury (IRI) is an inevitable complication associated with liver surgical procedures, and its pathological process remains elusive. Therefore, the present study investigated the role and mechanism of hypoxia-inducible factor-1alpha (HIF-1α) in hepatic IRI. Here, we constructed rat models w...

authors： Zhang X,Du P,Luo K,Li Y,Liu Z,Wang W,Zeng C,Ye Q,Xiao Q

更新日期：2021-12-01 00:00:00

abstract：:Gills of fish are involved in respiration, excretion and osmoregulation. Due to numerous interactions between these processes, branchial diseases have serious implications on fish health. Here, "koi sleepy disease" (KSD), caused by carp edema virus (CEV) infection was used to study physiological, immunological and met...

authors： Adamek M,Teitge F,Baumann I,Jung-Schroers V,El Rahman SA,Paley R,Piackova V,Gela D,Kocour M,Rakers S,Bergmann SM,Ganter M,Steinhagen D

更新日期：2021-12-01 00:00:00

abstract：:N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) hydrolase that catalyses the intracellular deactivation of the endogenous analgesic and anti-inflammatory agent palmitoylethanolamide (PEA). NAAA inhibitors counteract this process and exert marked therapeutic effects in animal models of pain, i...

authors： Ghidini A,Scalvini L,Palese F,Lodola A,Mor M,Piomelli D

更新日期：2021-12-01 00:00:00

abstract：:Hematite nanoparticles possess unique properties which have motivated substantial attention for numerous applications, including environmental remediation and wastewater treatment as a promising novel technology. The magnetite-silicate raw material of Kiruna-type ore has been introduced as an innovative precursor, dec...

authors： Mostaghelchi M,Zendehbad M,Lengauer CL

更新日期：2021-12-01 00:00:00

abstract：:The vascular endothelial growth factor receptor 2 (VEGFR2) is considered to be a pivotal target for anti-tumor therapy against angiogenesis of non-small cell lung cancer (NSCLC). However, effective and low-toxicity targeted therapies to inhibit VEGFR2 are still lacking. Here, biRGD-siVEGFR2 conjugate comprising murine...

authors： Liao L,Cen B,Li G,Wei Y,Wang Z,Huang W,He S,Yuan Y,Ji A

更新日期：2021-12-01 00:00:00

abstract：:The increase of harmful carbon monoxide (CO) caused by incomplete combustion can affect human health even lead to suffocation. Therefore reducing the CO discharged by vehicles or factories is urgent to improve the air quality. The spinel cobalt (II, III) oxide (Co₃O₄) is an active catalyst for CO abatement. In this st...

authors： Tang CW,Shih HY,Wu RC,Wang CC,Wang CB

更新日期：2021-12-01 00:00:00

abstract：:Bio-fabrication of iron oxide nanoparticles by using different sources of plants, plant parts and microbial cells have become a great topic of interest nowadays due to its eco-friendly nature. The stabilizing and capping agents in biological sources are biocompatible, stable and non-toxic which make its use beneficial...

authors： Yadwade R,Kirtiwar S,Ankamwar B

更新日期：2021-12-01 00:00:00

abstract：:Lithium sulfur battery has become one of the promising rechargeable battery systems to replace the conventional lithium ion battery. Commonly, it uses carbon-sulfur composites as cathode materials. Biomass based carbons has an important role in enhancing its electrochemical characteristics due to the high conductivity...

authors： Andreas Arie A,Lenora S,Kristianto H,Frida Susanti R,Kee Lee J

更新日期：2021-12-01 00:00:00

abstract：:This study aimed to screen key biomarkers and investigate immune infiltration in pulmonary arterial hypertension (PAH) based on integrated bioinformatics analysis. The Gene Expression Omnibus (GEO) database was used to download three mRNA expression profiles comprising 91 PAH lung specimens and 49 normal lung specimen...

authors： Zeng Y,Li N,Zheng Z,Chen R,Liu W,Cheng J,Zhu J,Zeng M,Peng M,Hong C

更新日期：2021-12-01 00:00:00

abstract：:Pristine TiO₂ and x% Ru/TiO₂ catalysts with different wt.% of Ru (x%= 1.5%, 2%, 2.5% and 3%) were synthesized using sol-gel and simple impregnation methods. Different characterization techniques such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Scanning electron microscopy (SEM), High-r...

authors： Kumaravel S,Thiripuranthagan S,Erusappan E,Sivakumar A,Kumaravel S,Natesan B,Rajendran K

更新日期：2021-12-01 00:00:00

abstract：:Based on many studies, trichosanthin (TCS) has an antiviral effect that regulates immune response, and targets cancer cells to exert broad-spectrum anti-tumor pharmacological activities. It is speculated that TCS may be a potential natural active drug for preventing as well as treating cervical cancer. But the clearer...

authors： Zhu C,Zhang C,Cui X,Wu J,Cui Z,Shen X

更新日期：2021-12-01 00:00:00

abstract：:The aim of this paper was to use chromatographic tools for validating an analytical method for the tacrolimus (TAC) determination in polymeric nanocapsules and for identifying the drug degradation products after alkaline stress. A rapid Ultra-High-Performance Liquid Chromatography coupled with photo-diode array (UHPLC...

authors： Camargo GA,Lyra AM,Barboza FM,Fiorin BC,Beltrame FL,Nadal JM,Novatski A,Farago PV

更新日期：2021-12-01 00:00:00

abstract：:Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. The oestrone halides with halogen atoms at both C-2 and C-4 positions (13β-, 13α...

authors： Sinreih M,Jójárt R,Kele Z,Büdefeld T,Paragi G,Mernyák E,Rižner TL

更新日期：2021-12-01 00:00:00

abstract：:Adipogenesis is regulated by genetic interactions, in which post-transcriptional regulation plays an important role. Staufen double-stranded RNA binding protein 1 (Staufen1 or STAU1) plays diverse roles in RNA processing and adipogenesis. Previously, we found that the downregulation of STAU1 affects the expression of ...

authors： Liang X,Jiao Y,Gong X,Gu H,Nuermaimaiti N,Meng X,Liu D,Guan Y

更新日期：2021-12-01 00:00:00

abstract：:Glucocorticoid (GC) hormone has been commonly used to treat systemic inflammation and immune disorders. However, the side effects associated with long-term use of high-dose GC hormone limit its clinical application seriously. GC hormone that can specifically target the lung might decrease the effective dosage and thus...

authors： Weng D,Yin ZF,Chen SS,He X,Li N,Chen T,Qiu H,Zhao MM,Wu Q,Zhou NY,Lu LQ,Tang DL,Song JC,Li HP

更新日期：2021-12-01 00:00:00

abstract：:The worldwide spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the most severe public health crisis since the 1918 Spanish influenza pandemic. After the introduction of public health interventions aimed at reducing the number of COVID-19 cases, many countries across the world obtai...

authors： Silva SJRD,Pena L

更新日期：2021-12-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a common human malignancy. However, its pathogenesis and prognostic information are poorly elucidated. In the present study, we aimed to probe the most significant differentially expressed genes (DEGs) and their prognostic performance in OSCC. Multiple microarray datasets from th...

authors： Zhao Y,Huang J,Chen J

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:A portion of patients with chronic myeloid leukaemia (CML) develop resistance to the Bcr-Abl tyrosine kinase inhibitors (TKIs), limiting the clinical applications. Previous results have demonstrated the synergistic effects between cryptotanshinone (CPT) and imatinib on apoptosis of CML cells in vitro. OBJECTIV...

authors： Cheng R,Huang Y,Fang Y,Wang Q,Yan M,Ge Y

更新日期：2021-12-01 00:00:00

abstract：:Most medical students receive inadequate preparation to care for sexual and gender minority (SGM) patients. A review of one urban medical school's pre-clinical curriculum was conducted to assess coverage of appropriate SGM health content. Curricula that fully or partially addressed American Association of Medical Coll...

authors： Pratt-Chapman ML,Abon N

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Pien-Tze-Huang (PTH) is traditionally applied to treat various inflammation-related diseases including stroke. However, literature regarding the anti-inflammatory effects and possible mechanisms of PTH in ischaemic stroke is unavailable. OBJECTIVE:This study investigates the anti-inflammatory effects and its u...

authors： Zhang X,Zhang Q,Huang L,Liu M,Cheng Z,Zheng Y,Xu W,Lu J,Liu J,Huang M

更新日期：2021-12-01 00:00:00

abstract：:The prognosis of patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC) is generally poor. New treatments are required to supplement the current standard of care. Paclitaxel (PTX), an effective chemotherapeutic for HNSCC, has serious side effects. A polymeric nanocarrier system was developed ...

authors： Riestra-Ayora J,Sánchez-Rodríguez C,Palao-Suay R,Yanes-Díaz J,Martín-Hita A,Aguilar MR,Sanz-Fernández R

更新日期：2021-12-01 00:00:00

abstract：Background:Catastrophizing is an important psychological construct in mediating the behavioral response toward pain. Objective:The purpose of this study is to examine the psychometric properties of the Pain Catastrophizing Scale (PCS) in Greek clinical population. Methods:The scale was administered in 376 patients wi...

authors： Christakou A

更新日期：2021-12-01 00:00:00

abstract：:Oral candidiasis is one of the most common types of fungal infection caused by Candida albicans (C. albicans). The present study aims to investigate the antifungal effects of phloretin (a dihydrochalcone flavonoid) against the C. albicans pathogenicity. In this work, we treated C. albicans SC5314 with 37.28, 74.55, or...

authors： Liu N,Zhang N,Zhang S,Zhang L,Liu Q

更新日期：2021-12-01 00:00:00

abstract：:The aim of this study was to identify hub genes closely related to the pathogenesis and prognosis of thyroid carcinoma (THCA) by integrated bioinformatics analysis. In this study, through differential gene expression analysis, 1916 and 665 differentially expressed genes (DEGs) were obtained from The Cancer Genome Atla...

authors： Pan Y,Wu L,He S,Wu J,Wang T,Zang H

更新日期：2021-12-01 00:00:00

abstract：:In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its in vitro chemical and enzymatic hydrolysis stability. Predicted in silico physicochemical properties of the newly synthesised hybrid (3) demonstrated a drug-li...

authors： Salerno L,Vanella L,Sorrenti V,Consoli V,Ciaffaglione V,Fallica AN,Canale V,Zajdel P,Pignatello R,Intagliata S

更新日期：2021-12-01 00:00:00

abstract：AIM:Podocyte injury plays an important role in diabetic nephropathy (DN), yet the underlying molecular mechanisms of podocyte injury in DN is not clear. Here, we investigated the role of activating transcription factor 4 (ATF4) and HO-1 in DN-induced podocyte injury. METHODS:Protein expression was measured by western ...

authors： Yuan S,Liang X,He W,Liang M,Jin J,He Q

更新日期：2021-12-01 00:00:00

abstract：:A new series of sulphonamide derivatives bearing naphthalene moiety were synthesised and evaluated for their antiproliferative and tubulin polymerisation inhibitory activities. These new compounds were evaluated for their in vitro antiproliferative activity against MCF-7 and A549 by using CCK-8 method. Among all the t...

authors： Wang G,Fan M,Liu W,He M,Li Y,Peng Z

更新日期：2021-12-01 00:00:00

abstract：:Microtubules (MTs) control cell shape and intracellular cargo transport. The role of MT turnover in the migration of slow-moving cells through endothelial barriers remains unclear. To irreversibly interfere with MT disassembly, we have used the MT-stabilizing agent zampanolide (ZMP) in Β16F10 melanoma as amodel of slo...

authors： Roncato F,Regev O,Yadav SK,Alon R

更新日期：2021-12-01 00:00:00

abstract：:To probe into the impact of Bupivacaine on colorectal cancer (CRC) proliferation, apoptosis, and autophagy through regulating the NF-κB signaling pathway. Our work treated CRC cells with Bupivacaine, detected cell vitality through MTT assay, apoptosis through flow cytometry, cell migration through wound healing assay,...

authors： Liu B,Yan X,Hou Z,Zhang L,Zhang D

更新日期：2021-12-01 00:00:00

abstract：:Spinal cord injury (SCI) is a refractory disease often accompanied by inflammation. Long non-coding RNA NEAT1 (lncRNA NEAT1) was reported to be involved in the expression of the inflammasomes, while the regulatory effect of NEAT1 on SCI was poorly investigated. Herein, we carried out further studies on the pathogenesi...

authors： An Q,Zhou Z,Xie Y,Sun Y,Zhang H,Cao Y

更新日期：2021-12-01 00:00:00

abstract：Background:Recently, some adverse effects of moxibustion has been reported such as burns, smoke, allergies, and so on. To overcome the adverse effects of traditional moxibustion, an ultrasonic moxibustion device (UMD) was designed, simulated, fabricated, and tested. The objective of this study is to provide detailed in...

authors： Kim G,Hwang YI,Ryu Y,Kim HJ,Bae YM,Kim KB

更新日期：2021-12-01 00:00:00

abstract：Background:Abdominal examination (AE), one of the primary diagnostic tools used in traditional Korean medicine (TKM), has a limitation of being subjective due to depending on individual practitioner's experience. Therefore, we devised a novel patient-report pressure algometer (PA) and performed a clinical trial to inve...

authors： Ko SJ,Kim KH,Lee SH,Yim MH,Park JW

更新日期：2021-12-01 00:00:00